What are megastructures of the future and how can it become a self-sustaining structure that embodies the idea of “mixed-use”?

This 7 million square feet project located on Pier 76 in New York City explores the integration of city infrastructure with mixed-use programs (such as hotel, education, residential, etc) and how sustainable synergies can arise from the various programs that are embedded within one singular megastructure. In 100 years in the future, with advanced technologies and extreme climate conditions (based on current climate trajectories), how can architecture transform into towers of ecological collaboration and celebration?