The Johns Hopkins Applied Physics Laboratory is a Federally Funded Research and Development Center (FFRDC) employing advanced physics and other interdisciplinary sciences to address complex research, analytical and engineering challenges related to critical national priorities and technology system development. Building 201 is a new, 263,000 GSF interdisciplinary research facility, currently under construction, that will house over 500 staff in a highly collaborative environment including electrical engineering, mechanical engineering, biological sciences/engineering, microelectronics/microsystems, multifunctional materials and nanostructure prototyping laboratories supported by a readily adaptable utility infrastructure. The project is  registered with a LEED Silver target. The six-level structure, organized around a central atrium, includes lower level laboratory space housing costly, vibration and electro-magnetically sensitive technical instrumentation requiring specialized sub-grade concrete and waterproofing construction. Located within a new district of the APL campus, the project includes an independent utility plant integrated into the building at the lower and roof levels. The project was designed with multiple bidding alternates to assure conformance to the allocated funding and completion within the project schedule. CannonDesign provided the programming, feasibility study, preliminary design, final design and construction administration services including architecture, interior design, structural engineering, MEP/FP engineering, cost estimating and overall project management/administration. CannonDesign has coordinated with a CM at Risk for the project delivery.